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Due to the significant interaction term for the anxiety model, LS mean differences were compared for challenge material (MSG v

For example, Gong and colleagues designed and synthesized a novel anti-anaplastic lymphoma kinase (ALK) degrader, PROTAC 27 , in which the piperazine moiety of the target ligand was directly linked to the acetamide group of (2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)glycine using the coupling agent HATU in DIPEA and DMF overnight