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Knuckle Pigmentation as an Early Cutaneous Sign of Vitamin B12 Deficiency: A Case Report PMC Hyperpigmentation in Vitamin B12 Deficiency New England Journal of Medicine Understanding Vitamin B12 Injections for Peripheral Neuropathy Those White Spots on Your Arm Could Be a Sign of a Vitamin B12 Deficiency Acquired hyperpigmentation, often on the hands and feet, can be a sign of vitamin B12 deficiency. It is reversible once the B12 deficiency is corrected. Keep in mind, this isn't the only
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