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This occurs when there's an imbalance between the generation and buildup of reactive oxygen species (ROS) within cells and tissues and the ability of innate biological systems and dietary antioxidants to eliminate these reactive byproducts

The motheaten phenotype is due to a splicing mutation in SHP1 causing an absence of detectable protein and mice that have severe disorders of hematopoietic cells resulting in death within 3 weeks after birth (148)

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Suciu M, Gruia AT, Nica DV, Azghadi SMR, Mic AA, Mic FA

These advances underscore how nanomedicine, through spatiotemporal precision, multi-target synergy, and pathological microenvironment responsiveness, provides novel strategies to overcome DN treatment bottlenecks