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The liver is continuously exposed to all ingested substances absorbed through the intestinal tract via the portal vein and systemically via the arterial blood supply

By consolidating mechanistic insight, clinical validation, safety profiling, pharmacokinetic challenges, and translational strategies into a unified model, this manuscript aims to provide an evidence-based and clinically actionable framework that extends beyond prior narrative summaries

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10.3390/ijms22095010 4 AquilanoK.BaldelliS.CirioloM