glutathione pathway breast cancer metabolism in progression and treatment resistance Excessive glutathione intake contributes to

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Hyperactivation of macrophages and intense secretion of pro-inflammatory cytokines lead to increased pulmonary edema that reduces the gas diffusion in the alveoli leading to hypoxia and in severe cases, respiratory failure (Moldoveanu et al., 2009

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The authors proposed that SFN could be administered as an adjunct to chemotherapy to reduce side effects [72]