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Seven days after TDM introduction, CD11b + CD45 + macrophages with high surface expression of M1 (inflammatory)-like markers CD38 and CD86 were found in the pathological areas of mouse lung tissues ( Effect of CD38 on Macrophage Proliferation and Polarization Macrophages exert an effector function against invading microorganisms

The tubes were cured overnight under a UV light (purchased from a local hardware store, 0.25 mW/cm 2 254 nm, measured on UVX radiometer)

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In addition, bacteria-derived LPS increases Toll-like receptor 4 (TLR4) activity and activates downstream NF-B signaling to promote inflammation and barrier dysfunction 69