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87 In acute opioid withdrawal, locus coeruleus firing rates increase and are associated with OWS

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For example, ROS can activate nuclear factor kappa B (NF-B), a key transcription factor that regulates the expression of pro-inflammatory cytokines, chemokines, and adhesion molecules [134]

Clinical pharmacokinetic studies have revealed a "bioavailability paradox": taking EGCg on an empty stomach drastically increases its absorption (up to 3.9 times higher than when taken with food), but doing so also exponentially increases the risk of severe side effects