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79,80 Endothelial cells secrete the PDGF-B to bind PDGFR on pericytes, which recruits pericytes to blood vessels

Finally, a kavalactone analog, namely Compound 1, strongly inhibited LPS-stimulated iNOS induction and NO production, as well as Nrf2 signaling potentiation in vitro in microglial cells, highlighting the potential of kavalactone analogs to reduce neuroinflammation and maintain redox homeostasis [64]