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Aberrations in Notch-Hedgehog signalling reveal cancer stem cells harbouring conserved oncogenic properties associated with hypoxia and immunoevasion

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Furthermore, persistent activation of the TCR and the type I IFN- signalling triggered mitochondrial changes via increasing NAD + consumption due to both CD38 overexpression and PARP activation in CD8 + T cells, resulting in lower spare respiratory capacity, decreased bioenergetic fitness and thus increased tendency to die

Meanwhile, immunofluorescence (IF) assay was used to investigate the degree of myotube hypertrophy

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