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10.1016/j.ijpharm.2022.121811 69 LiuY.ChenL.LiuX.TaoR.DongR.WangX.et al (2025)

Multi-dose puncture studies: standard handling protocols are based on 28-day post-puncture sterility data underpinning USP and BP monographs

Longitudinal monitoring, therefore, represents a more clinically meaningful approach

Compared to the UBE2m RK, the re-introduction of UBE2m WT promoted NEDD4 neddylation in UBE2mKO HK-2 cells, while NEDD4 neddylation could not be induced by the vector alone (Fig