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del Cura Gonzlez I Article: DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

28 RezvaniA

Author / review note Reviewed by the FormBlends Medical Team

In a transgenic mouse model of familial Alzheimers disease (5xFAD mice, which exhibit the human amyloid precursor protein and presenilin 1 transgenes with five mutations linked to Alzheimers disease), intracranial injection with Salmonella typhimurium resulted in a dramatic increase in A deposition after only 48 h 13

Moreover, to the endogenous production of L-arginine oxidation, there is a metabolic oxidation pathway, --NO, which is independent of the NO synthases (NOS) (97)