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Glutathione-mediated antioxidant response and aerobic metabolism: two crucial factors involved in determining the multi-drug resistance of high-risk neuroblastoma

Lipoic acid increases de novo synthesis of cellular glutathione by improving cystine utilization

Kopustinskiene DM, Bernatoniene J

The CNSs high metabolic demand renders it particularly vulnerable to oxidative injury

Finally, a hormetic effect with 3 M of synthetic -carotene has been associated with reduced tumor-destroying capability of NK cells in vitro, whereas lower doses enhance this activity, and, while low concentrations of -carotene do not affect erythrocyte or leukocyte viability, high concentrations significantly reduce viability [52]