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3b), smoking induced remarkable transcriptional upregulation in tuft-like cells and downregulation in both ionocytes and PNECs (Fig

Effects on gas transport and oxygen delivery: As was discussed above, the carbon monoxide in smoke binds to hemoglobin with much higher affinity than oxygen, forming carboxyhemoglobin and reducing the effective oxygencarrying capacity of blood

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Acting FDA commissioner Ned Sharpless said companies must present scientific evidence before marketing products as less risky than tobacco

doi: 10.1046/j.1460-9568.2002.02089.x