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While these 48 studies formed the core evidence for the health claim, the EFSAs evaluation process also considered additional scientific data related to hydroxytyrosol and its derivatives

Harsh chemicals like hydroquinone, which have been used historically for skin lightening, can cause side effects such as skin irritation, ochronosis (a bluish-black discoloration), and even increased risk of cancer with prolonged use

While the concentration of research within a single group has drawn some scientific criticism regarding independent verification, it has also produced an unusually coherent and detailed body of knowledge about a single compound

It is interesting to note, however, that post-chemotherapy GSTP1 expression was associated with progression-free survival in a small study ( n =41 patients) where pre- and post-chemotherapy biopsies were available (Saip et al, 2005)

Li, T., Copeland, C