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irritans could be a biomarker for oxidative stress induced by zinc ions

Das D, Pham HTT, Lee S, Noh I (2019) Fabrication of alginate-based stimuli-responsive, non-cytotoxic, terpolymric semi-IPN hydrogel as a carrier for controlled release of bovine albumin serum and 5-amino salicylic acid

For prostanoid generation, both COX-1, which is constitutively expressed by most cells, and COX-2, an inducible isoform upregulated by inflammatory mediators such as lipopolysaccharide, IL-1, IL-6, or tumor necrosis factor- (TNF-), convert AA into prostaglandin endoperoxides (PGs), such as prostaglandin G 2 (PGG 2 ) (Ramsay et al., 2003

Glutathione and Vitamin C are often used together because both provide antioxidant benefits and may support a brighter-looking complexion