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FIGURE 1 There are several examples of drugs becoming toxic/bioactive following their conjugation with GSH

Sleeping beauty: quiescence in Saccharomyces cerevisiae

Mediterranean diet: The role of long-chain -3 fatty acids in fish

In macrophages, heme is first decomposed to generate biliverdin by heme oxygenase-1 (HO-1), which then undergoes reduction to bilirubin by biliverdin reductase(BVR) (5, 6) ( Figure 1 )