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For instance, research has shown that the depletion of microglia in the brain significantly increases vascular leakage during hypoxia, which is correlated with astrocyte-vascular uncoupling and a loss of TJ proteins [63]

This phosphorylation leads to signaling cascades that can activate gene transcription through the complex formation between receptor and the mitogen (Gmez and Cohen, 1991)

Disrupting key steps in ECM remodeling, including matricellular protein deposition, collagen crosslinking, and mechanotransduction, represents a promising strategy to halt fibrosis progression

doi:10.1023/A:1020904317133

Fonseca A, Frazier AL, Shaikh F (2019) Germ Cell Tumors in Adolescents and Young Adults