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Van Aardt M, Duncan SE, Marcy JE, Long TE, OKeefe SF, Nielsen-Sims SR

Objective: Use data from a prospective, multi-center adult cohort of AATD ZZ subjects with protocol enrollment liver biopsies to identify the prognostic value of clinical markers and biopsy for the development of severe liver disease outcomes

2011 Jan;24(1):10-8

A peripheral blood smear would show hypersegmented neutrophils, with a portion of the neutrophils having greater than or equal to five lobes

This diversity in upstream signaling implies that MSCs adapt to distinct pathological microenvironments through specific factors, which ultimately converge to activate Nrf2