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10.1016/j.ecofro.2024.02.014 21 El-SayedA.-F

A C-terminal signal prevents secretion of luminal ER proteins

Caspase-independent cell death in lung cancer: from mechanisms to clinical applications

Simultaneously, under hypoxic or pathological stimuli, dysregulated non-coding RNAs act as key regulators by interfering with Glutathione Peroxidase (GPX4)-mediated antioxidant defense and acyl-CoA synthetase long-chain family member 4 (ACSL4)-mediated lipid metabolism [130, 131], leading to Fe 2+ overload and the accumulation of lipid peroxidation products malondialdehyde (MDA)