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KO clones lacking each cell death executor were created using CRISPRCas9 technology

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First, the model employed -naphthylisothiocyanate-induced cholestasis, which is an acute injury model

These findings suggest a substantial degree of central sensitization in cirrhosis, highlighting nociplastic pain as a crucial component of chronic pain in these patients (68, 81)

7c), but the mice received XMU-MP-1 prior to KA injection (KA + XMU-MP-1 mice) required additional injection of KA to reach to the same seizure stage compared to that in DMSO-pretreated epileptic mice (KA + DMSO mice)