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Persistent STAT3 activation can induce antiapoptotic proteins (e.g., Bcl-2 and Mcl-1) and angiogenic factors [e.g., vascular endothelial growth factor (VEGF)], forming a microenvironment conducive to tumor growth

Upon binding, IGF-1R activates two downstream pathways: the PI3K/Akt pathway (driving protein synthesis and glucose uptake) and the MAPK/ERK pathway (promoting cell proliferation and differentiation)

Both the cellular invasion and the metabolic activity of the parasite alter the cell membrane, leading to splenic sequestration

Atorvastatin also improved microvascular reactivity and reduced the oxidative stress marker malondialdehyde in patients with HFpEF (Iacovelli et al., 2024), and Simvastatin significantly decreased protein carbonylation (an oxidative stress marker) in COPD patients