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doi: 10.1371/journal.pone.0028958 40 EbrahimifardN.HadifarS.Kargarpour KamakoliM.BehrouziA.KhanipourS.FatehA.et al

PD-1/PD-L1 checkpoint blockade harnesses monocyte-derived macrophages to combat cognitive impairment in a tauopathy mouse model

Their anti-inflammatory function not only helps regulate the immune response but also promotes cognitive function

1) to the nucleus, and nuclear trafficking of most proteins is controlled by the small GTPase, Ran [7]

Consequently, this reduces severe pathological histomorphological modifications induced by platinum on the foetus and placenta as well as minimising the likelihood of degeneration and apoptotic cell death of spermatogonia in the testes (