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New treatments targeting interactions between synapses and glial cells, such as CSF1R inhibitors and anti-C1q antibodies, are being tested

Yu H, Zhou Y, Lind SE, Ding WQ

48 The regulation of XBP1s can govern the redox balance by modulating the expression of antioxidant enzymes

Many spin traps react relatively ineffectively with superoxide (e.g., PBN has weak in vitro antioxidant activity), so high doses are required to achieve a therapeutic benefit