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DNAzymes have demonstrated well-tolerability in clinical trials targeting c-jun and EBV LMP1 proteins, because these molecules can cross the BBB following systemic injection, eliminating the need for direct brain injections 11

[DOI] [PMC free article] [PubMed] [Google Scholar] 105.Vilchez D, Simic MS & Dillin A

SONFH, Steroid-induced osteonecrosis of the femoral head

(32) demonstrated that DFO and deferasirox protect retinal neurons by mitigating Fe 2+ accumulation, reducing the expression of oxidative stress markers, and decreasing RGC loss