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Additionally, exercise has been demonstrated to positively alter neurotransmitter levels and brain structure in older adults (Yi et al., 2022

IL-6 receptor antagonists Tocilizumab a recombinant anti-human IL-6 receptor monoclonal antibody that binds to both soluble and membrane-bound IL-6 receptors, inhibiting IL-6 mediated signaling the AMBITION clinical trial found that it was slightly superior to methotrexate as monotherapy for RA, but had a slightly higher incidence of side effects (Jones et al, 2010) Janus Kinase Inhibitor Tofacitinib Inhibits cytokine & growth factor signalling by inhibiting Janus kinases, a family of intracellular tyrosine kinases

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J Histochem Cytochem 38:17451754 De Camilli P, Jahn R (1990) Pathways to regulated exocytosis in neurons