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The sample size of this study is relatively small ( n = 6 per group), which may limit the statistical power to detect subtle changes and represents a limitation of this research

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Women are affected more often than men

Interestingly, BSO treatment did not affect SLC25A39 mRNA levels (Extended Data Fig 1c), but could induce SLC25A39 protein accumulation when an SLC25A39 cDNA lacking UTR elements was expressed ectopically under a viral promoter (Extended Data Fig 1d), thereby suggesting regulation at the post-translational level