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The work on tissue-specific NAMPT-knockout murine models has shown that, in fact, NAM salvage is critical to maintain baseline NAD + levels, albeit to varying degrees in different cells and tissues

3 The SLC2A9 gene, which encodes the fructose/urate co-transporter GLUT9, has been implicated in the greater number of Mori and Pacific peoples living with gout (see: The burden of gout is more severe among Mori and Pacific peoples)

This result was further confirmed by western blot in U2OS cells, where NSD2 was undetectable upon treatment with 300 nM UNC12149 for 6 h (Supplementary Fig

Consistent with the mouse data, levels of BHB were increased in the serum of patients with influenza in comparison to healthy control individuals, indicative of infection-induced ketogenesis (Fig