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It occurs when the brain is overworked or under strain due to factors such as: Insufficient rest resulting in fatigue Lack of good dietary nutrition Accumulation of toxic heavy metals in the body or consumption of foods containing pesticide poisons Build-up of stress Presence of free radicals in the body Latent inflammation Lack of exercise Various hormonal imbalances Dehydration or insufficient intake of water Psychological disorders or other chronic health conditions All of the above can result in a deterioration of body functions, thus overtaxing the adrenal glands

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The British Journal of Psychiatry 2011

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But there is something unique in there, too, a harder facet of Keatons ability that I only wish shed gotten to, or chosen to, explore more of later in her career