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A more evidence-based way to evaluate whether something is helping is to track measurable outcomes with your clinician (for example, symptoms tied to confirmed deficiency, or objective metrics like body weight, waist measurements, and lab work when appropriate)

2.6 Areas to be investigated to expand research in the field of CD38 2.6.1 Fate of unbound therapeutic antibody One proposal is the selection of therapeutic antibodies that show negligible reactivity with red blood cells (RBC) and platelets, which are reported to express CD38 at a cell surface density too low to trigger lysis

And on a side note we also have a much better understanding of why our metabolism slows down as we get older