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Steroid therapy is known to cause glucose intolerance, hypertension, adrenal suppression, gastrointestinal bleeding, pancreatitis, osteoporosis, cataracts, myopathy, insomnia, altered mental status, and aseptic necrosis of the femoral or humeral heads [106]

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Although further research is needed to fully understand and exploit its potential, the current findings provide a foundation for future research and development

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Recent studies have suggested that urate transporters mutations in genes and related sites directly affect urate reabsorption and excretion (Guo et al., 2005