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Comparing DSIP with Epitalon and Orexin clarifies its role as a tool for investigating integrated neuroendocrine signaling, sleep architecture, and pathway-level interactions in experimental systems

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14,15 TNF alpha-induced protein 3 (A20) and CYLD lysine 63 deubiquitinase (CYLD) are key deubiquitinases in the downregulation of NF-B signaling