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For the latter, termed complex core diversification or late-stage functionalization, the synthetic power of this concept is readily apparent as the positional (as well as stereoisomeric) analogs of complex starting materials are accessed with high efficiency when compared to lengthy de novo approaches 30,31,32,33,34,35,36

Participants were recruited from visiting patients at the Toronto Centre for Liver Disease Clinic undergoing transient elastography (TE) that day or who had established cirrhosis