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If skin brightening is your aim, set realistic timelines and use medical supervision

Future Med Chem (2021) 13(4):3359

It's kind of like saving $50K off the price of a brand new Corvette and then driving an hour away every week to fill up at the crappy little no-name gas station that's 5 cents a gallon cheaper for 86 octane gas than the local Exxon selling 93 octane

For the patient, it is often associated with severe emotional distress

Key points Methylation changes can occur due to the loss of maintenance of methylation marks by the DNMT enzymes during cell division (passive demethylation) or by active removal of methylation marks by the TET enzymes (active demethylation)