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[52] However, at blood concentrations achieved via food fortification, folic acid has no known cofactor function that would increase the likelihood of a causal role for free folic acid in disease development

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By 1951, further refining of thiopurines led to the creation of 6-mercaptopurine (6-MP) and 6-thioguanine (6-TG) which were subsequently used to treat children with acute leukemias who up until that point only had corticosteroids and methotrexate available as treatments

The high SOD-like activity of the CuTA nanozyme was supported by the coordination environment around the Cu 2+ ions, which allowed the nanozyme to participate effectively in redox reactions