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A new selective inhibitor for uptake of serotonin into synaptosomes of rat brain: 3-(p-trifluoromethylphenoxy)

doi: 10.1002/art.30093 56 JoostenLALubbertsEHelsenMMvan den BergWB

The resulting data matrix of metabolite intensities for all samples and blank controls was processed using a custom statistical pipeline Metabolize v.1.0 and final peak detection was calculated based on a signal to noise ratio (S/N) of 3 compared with blank controls, with a floor of 10,000 (arbitrary units)

8 It is required for hepatic GSH synthesis and may be derived from methionine, which serves as a major source of cysteine, via the trans-sulfuration pathway of the liver

271 Cys102 and Cys153 in HDAC8 are integral to its redox switch, with disulfide bond formation under oxidative conditions potentially resulting in reversible enzyme activity loss