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But hes positive the theory that you know, and oxidative reactive oxygen species are released by the mitochondria to protect the cells from further damage in a dysfunctional cellular response, and it continues to be activated despite the neutralization of the threat and these reactive oxygen species act, dysfunctional, damaging healthy cells, and he says he had contrary to long held beliefs about the etiology of these diseases

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Depending on the nature of the neurons depolarization, NMDA-Rs can both strengthen synapses, through long-term potentiation (LTP) [32, 33], and weaken synapses, through long-term depression (LTD) [34]