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In this protocol, we favor a functional definition of SLP dependency as the comparatively limited capacity of malignant cells to sustain long-term proliferation when forced to use OXPHOS-exclusive metabolism (e.g., deprivation of glucose and glutamine, the two primary SLP fuels, at the substrate, transport, or utilization level)

Signal transducer and activator of transcription 3 (STAT3) binds to DNA response elements in the promoters of ferroptosis-related genes (FTH1, SLC7A11, and GPX4) and regulates their expression

For All Skin Types: Suitable for normal skin types and can be used daily

The authors acknowledge additional financial support from the UK Department of Health and Cancer Research UK via Experimental Cancer Medicine Center awards to Kings Health Partners/Guys & St Thomas NHS Foundation Trust (JS)

Frequently asked questions about L-carnitine Very high doses of the amino acid derivative L-carnitine can cause undesirable side effects such as gastrointestinal complaints and headaches, so the recommended daily intake should be observed