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Lipotoxicity in renal TECs is associated with inflammation, oxidative stress, mitochondrial dysfunction and cell death (27)

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In parallel, novel tracers targeting mitochondrial dysfunction and histone deacetylase (HDAC) activity [344 345, 353, 354, 355] provide tools to probe the molecular underpinnings of energy metabolism and epigenetic regulation

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A novel 11beta-hydroxysteroid dehydrogenase type1 inhibitor CNX-010-49 improves hyperglycemia, lipid profile and reduces body weight in diet induced obese C57B6/J mice with a potential to provide cardio protective benefits