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It could be used to reduce side effects, lower necessary drug dosages, or even slow or halt disease progression

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In fact, in vivo studies have shown that Nrf2 signaling has an essential role in limiting neuropathies (Arruri et al., 2017), arthritis (Ferrandiz et al., 2018), colitis (Xu et al., 2018), pneumonia (Athale et al., 2012), pulmonary fibrosis (Yan et al., 2017), skin diseases (Schafer and Werner, 2015), liver (Bae et al., 2013), and kidney damage (Shen et al., 2017), as well as affecting tumor development (Sporn and Liby, 2012)

Suppressive effect of RAS inhibitor manumycin A on aberrant crypt foci formation in the azoxymethane-induced rat colorectal carcinogenesis model

The study also recommends studying the impact of VCN on other molecular targets like the apoptotic-related targets (Bcl-2, BAX, and caspase) and the NOX family related to ROS production