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In a recent study from Hingert et al, 45 a secretome analysis conducted on BM-MSC conditioned media revealed 753 unique peptides, mostly represented by ECM proteins (20.16%), enzymes (22.48%), glycoproteins and proteoglycans (12.4%), and growth factors and their modulators (6.98%, including vascular endothelial growth factor, bone morphogenetic protein 1, connective tissue growth factor, insulin-like growth factor binding protein, metalloproteinase inhibitors, antiapoptotic factors, and several more

Furthermore, the autophagy mechanism was evident by the increase and accumulation of microtubule-associated protein light chain-3 (LC3) (Lee et al., 2014)

doi: 10.3390/antiox10010068

Question 5

Moreover, we showed that selected genes involved in redox metabolism are downregulated with aging