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However, the trialists attended training sessions prior to the initiation of the study which covered alternative approaches to smoking cessation, the chemical composition of snus, the epidemiology of snus use in Sweden, health effects of nicotine and snus versus cigarette smoking, how to use the study products, the need for adequate nicotine dosing to suppress cravings, methods for counseling of smokers who want to quit, and proper use of study equipment

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Smoking upregulates alpha4beta2* nicotinic acetylcholine receptors in the human brain

Available from: Gallus S, Lugo A, Liu X, Behrakis P, Boffi R, Bosetti C, et al