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Melasma primarily affects the face and occurs symmetrically on the cheeks, bridge of the nose, forehead, chin, and above the upper lip

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[97] Rodent models [edit] Mice that are genetically engineered to lack orexin genes demonstrate many similarities to human narcolepsy

These include the physiological and nutritional status of the animal (e.g., if an animal is deficient in a nutrient, bioavailability is often increased) and interactions among nutrients (e.g., high calcium levels reduce zinc bioavailability)