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doi: 10.1016/j.cellsig.2020.109820 69 ReynoldsMRLaneANRobertsonBKempSLiuYHillBGet al

Cytotoxicity assays Cells were plated into a 96-well plate at a density of 110 4 cells per well and incubated in a cell incubator (37 C, 5% CO 2 )

104 Under these conditions, lower ROS levels always along with alleviated mtDNA damage

Whats more, it supports detoxification by binding to harmful substances for elimination

Phosphorylated ATF1 further improves macrophage adaptation to intraplaque hemorrhage, thus maintaining the homeostasis under dural iron-lipid stress (178)