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: Individuals with severe B12 deficiency, people with difficulty absorbing B12 (due to digestive conditions), or those looking for long-lasting effects from injections

Yet, a randomized, double-blind, placebo-controlled trial in 215 men (35-55 years old) found that daily supplementation with B vitamins (at 3 to 13 times the current RDA, except for folic acid, which was included at a dose equivalent to the RDA), vitamin C (500 mg/day), zinc (10 mg/day), and magnesium (100 mg/day) for 33 days had no effect on measured performance of executive functions, including the Stroop color-word test, the peg-and-ball task, and the Wisconsin card-sorting task (134)

For example, in cities like Los Angeles or New York, an IV vitamin drip can cost $300$600, while the same service in a mid-sized city or suburb may be available for $100$250

Notably, in addition to synoviocytes, synovial macrophages also have an important role in synovial inflammation of OA [137]