foxo4-dri senolytic peptide animal model 2023 2024 improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells Computational design of peptide targeting

Computational design of peptide targeting FOXO4. a, Domains of FOXO4 Download Scientific Diagram Molecular modelling of the FOXO4 TP53 interaction to design senolytic peptides for the elimination of senescent cancer cells ScienceDirect Targeting the FOXO4 p53 axis by retro inverso peptide senolytic agents: a pharmacological strategy to mitigate brain aging and cognitive decline Naunyn Schmiedeberg's Archives of Pharmacology Springer Nature Link The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4 DRI Nature Communications FOX04 DRI Apollo Peptide Sciences

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