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While the focus of this section is on DNA methylation and hydroxymethylation in relation to oxidative stress, smoking, and cancer, we refer the readers to elegant and comprehensive reviews on other epigenetic mechanisms, such as histone modifications and variants, miRNA deregulation, chromatin remodeling, and nucleosome positioning [221, 223, 224, 264, 265], which fall outside the scope and space limit of this review article

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As such, their position on the relative risk hierarchy is determined mostly by the LCR analysis

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