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Mutations in the relevant sites of MTHFR gene can result in a decrease in the enzyme activity of the MTHFR protein, leading to a deficiency of methylenetetrahydrofolate, which can eventually lead to a decrease in the degree of DNA methylation and microsatellite instability, and ultimately can induce colorectal neoplasm [2, 3, 17]

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Expert Opin Biol 2:847-856, 2002

Khoo ML, Tao H, Meedeniya AC, Mackay-Sim A, Ma DD

Chen YS, Guo Q, Guo LJ, Liu T, Wu XP, Lin ZY, et al