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Several phase II clinical trials are presently being conducted

These patients exhibit lower numbers of retrieved oocytes, lower quality of oocytes, lower number of embryos and quality of embryos, and lower rates of blastocyst formation ( A key hypothesis we are studying here is that in endometriosis, a pro-oxidant microenvironment in the local vicinity of the follicle created by an unbalanced redox state detrimentally impacts the quality of oocytes, sperm, and embryos, hampering their cellular function, jeopardizing their viability, and that this is a fundamental underlying cause of diminished fertility with endometriosis

However, researchers soon found that VIP has widespread effects beyond digestion, influencing processes such as immune regulation, blood flow, and cellular signaling

J Biol Chem 282(45):3321033217

Evidence for spironolactone treatment in female pattern thinning A 2023 systematic review and meta-analysis evaluated oral use in women