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Description

Blood 117 , 66006607 (2011)

It seems that cytokine storm phenomenon in elderly patients with severe COVID-19 infection, is associated with many age-related pathophysiologic processes, including alteration of angiotensin-converting enzyme 2 (ACE2) receptor expression [9], excess ROS production [10], alteration of autophagy [11], the inflammatory phenotype of senescent cell activity, particularly adipose tissue [12], and immune-senescence [13], as well as lack of vitamin D content [14]