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Genistein exhibits therapeutic potential for PCOS mice via the ER-Nrf2-Foxo1-ROS pathway

Studies suggest initiating therapy at lower concentrations (2.5-5%) and titrating upward to minimize irritation-induced PIH in Indian skin

Galla et al., 2018)

Neurotransmission alterations Another pathogenic mechanism in HE associated with energy disturbances is the alteration in neurotransmission systems, such as the glutamatergic and GABA-ergic systems, resulting in neuronal disinhibition (mechanism described in Fig